TP53 and non-small cell lung carcinoma: Considering the repeated reports of co-occurrence of TP53 and EGFR variants in LUAD, including the present study, we hypothesize that occurrence of an activating EGFR somatic event on a background of a tissue already harboring a mutant (germline) TP53 allele (such as c.1010G>A) may result in an impairment of this loop function, promoting NSCLC formation and tumor growth (Figure 1B).