Unlike most TP53 somatic and/or germline deleterious variants involved in tumorigenesis (i.e., those located in the DNA-binding domain of p53 protein), c.1010G>A is located in the p53 oligomerization domain and has been associated with a unique intracellular pH-dependent effect on protein stability, through which the mutant protein retains some partial tumor suppressor activity (DiGiammarino et al., 2002; Zerdoumi et al., 2017). The gene discussed is TP53; the disease is neoplasm.