The late onset of LC in TP53 c.1010G>A carriers is in agreement with a recent finding showing a lifelong cancer risk pattern characterized by a bimodal age distribution: one peak in the first 10 years of life associated mainly with ACC and CNS tumors, and a second peak in the fifth decade in which different tumor types occur, including LC (Mastellaro et al., 2017). Here, TP53 is linked to central nervous system neoplasm.