TP53 and laryngotracheoesophageal cleft: Lung cancer (LC), especially lung adenocarcinoma (LUAD) of the lepidic subtype, has been reported in LFS families and is included in the Chompret criteria for genetic testing of suspected patients, but there is limited evidence for a strong association of its occurrence with germline TP53 variants (Tinat et al., 2009; Ricordel et al., 2015; Caron et al., 2017).