Although LC (especially LUAD) is not among the core, most frequent tumors originally described in LFS, it has been described in Brazilian LFS families with the TP53 c.1010G>A variant (Barbosa et al., 2020), together with other atypical tumors such as papillary thyroid and renal cancers (Achatz and Zambetti, 2016). This evidence concerns the gene TP53 and laryngotracheoesophageal cleft.