Further, evidence recommends that liver stem/progenitor cells are the potential source of intrahepatic cholangiocarcinoma (ICC) and SCF/c-kit system might contribute to ICC by promoting cell proliferation and survival (Nomoto et al., 2006; Komuta et al., 2008; Mansuroglu et al., 2009b). The gene discussed is KITLG; the disease is intrahepatic cholangiocarcinoma.