Disruption of the TGF-β/KIT signaling loop on the level of the SCF/STAT3 axis restores TGF-β tumor suppressor function by inhibition of epithelial-mesenchymal transition (EMT), tumor cell migration, and invasion, and restoration of its cell cycle inhibitory functions (Rojas et al., 2016). Here, TGFB1 is linked to neoplasm.