CCL2 and metabolic dysfunction-associated steatohepatitis: Besides, chemokines such as monocyte chemoattractant protein 1 (MCP-1)/CCL2, RANTES/CCL5, and other CXC chemokines have gained special importance in the progression of NAFL to NASH by regulating insulin resistance and steatosis via the inflammatory crosstalk between liver and adipose tissue (44).