A human breast cancer line MDA-MB-231 stable lines with CtrlKD, CD47KD, ATP6AP2KD, or a double knockdown were established by CRISPR/Cas9 (Figure S2B) and injected into the mammary fat pad of RAG2-/-, γc-/- mice (Figures 4C, D). The gene discussed is GC; the disease is breast cancer.