Lysosomal destabilization-induced activation of the NLRP3 inflammasome is the feature of particulate matter and crystalline, elucidating the pathological mechanisms of the relevant inflammatory diseases, including amyloid β with Alzheimer’s disease, monosodium urate with gout, cholesterol crystalline with atherosclerosis, silica with silicosis, and asbestos with asbestosis. This evidence concerns the gene NLRP3 and early-onset autosomal dominant Alzheimer disease.