PTGS2 and colitis: In fat-1 mice, a transgenic mouse model that can efficiently convert n-6-PUFAs to n-3-PUFAs allowing controlled studies without dietary manipulation, the effect of endogenously synthesized n-3-PUFAs attenuated DSS-induced colonic inflammation accompanied by significant decreases in PGE2 production and COX2 expression as well as decreases in colitis-induced pro-inflammatory cytokines, monocyte chemoattractant proteins (MCP-1, -2, -3) and matrix metalloproteinase 9 (261).