In another study, DHA was as effective as sulfasalazine treatment in reducing DSS-induced colitis severity in BALB/c mice, partly by modifying DSS-responsive genes, namely pro-inflammatory cytokines IL-1β, CD14 antigen and TNF receptor superfamily member 1b (Tnfrsf1b), membrane remodeling protein (Mmp-3, -10, and -13) and acute phase protein (S100a8) (174). This evidence concerns the gene TNFRSF1B and colitis.