In UC-IBD, De Smet et al. (311) found that a lack of ghrelin delayed neutrophil infiltration and decreased disease activity index in a model of chronic DSS-colitis, whereas in C.rodentium-induced colitis (312) the late stages of infection were associated with increased ghrelin expression, with in vitro studies showing ghrelin induced marked proliferation of neurons. Here, GHRL is linked to infection.