For example, in unchallenged C57BL/6 mice, the protective effect of dietary supplementation with different extra-virgin olive oil cultivars on DSS-colitis severity in C57BL/6 mice, including reduction of IL-1β, TGF-β and IL-6 expression levels, was only observed in mice treated with cultivars Ogliarola, Coratina, or Cima di Mola, but not for Peranzana cultivar (14). The gene discussed is IL6; the disease is colitis.