Zarepoor et al. (93) found that ground flaxseed supplementation (10%, 6%, 4%) given to C57BL/6 mice (from Charles River Laboratories, Portage, MI) fed a AIN-93G basal diet worsened DSS-colitis and inflammatory cytokines (colonic tissue and systemically IL-6, IL-1β) and NF-κB related signaling genes (Nfkb1, Ccl5, Bcl2a1a, Egfr, Relb, Birc3, and Atf1). The gene discussed is IL1B; the disease is colitis.