In another study, 2,4,6-trinitrobenzenesulfonic acid (TNBS)-colitis rats given n-3-PUFA orally showed inhibition of pro-inflammatory eicosanoids, prostaglandin E2 (PGE2), and leukotriene, similar to treatment with 5-aminosalicylic acid (Peroxisome proliferator-activated receptor gamma; PPARγ agonist) (53), whereas others have suggested a decreasing effect over time, due to T-cell apoptosis/regrowth (56). This evidence concerns the gene PPARG and colitis.