In one study, attenuation of spontaneous ileitis in SAMP1/Yit mice by n-3 PUFA was due to inhibition of monocyte recruitment in the inflamed tissues (55), while two other studies in C57BL/6 mice showed that n-3-PUFAs exacerbated DSS-colitis due to decrease of adiponectin expression, one of which noting no change with n-6-PUFA or control diets (52, 54). This evidence concerns the gene ADIPOQ and colitis.