ADIPOQ and colitis: While several studies have suggested adiponectin to have anti-inflammatory activity (292), more recent studies have implicated its role in the pathophysiology of colitis, although its role remains controversial (293, 294) with some studies reporting an attenuated effect on colitis while others suggest that decreased adiponectin in colon subepithelial myofibroblasts exacerbates colitis (52, 295, 296).