However, in BALB/c mice fed a high-fat, high-sugar diet, only low-dose ALA supplementation (150 mg/kg vs. 300 mg/kg) was protective against TNBS-colitis resulting in significantly lower colonic IL-1, IFNγ, IL-4 and IL-2 cytokine production (97). The gene discussed is IFNG; the disease is colitis.