Attenuation of TNBS-colitis Sprague-Dawley rats administered dietary n−3-PUFAs (20 mg/day, intragastrically) was associated with enhanced PPARγ expression with a concomitant decrease in NFAT expression when compared to trans-FA (13 mg/day) treated rats, indicating that n-3-PUFA inhibits NFAT, potentially via PPARγ activation (50). The gene discussed is PPARG; the disease is colitis.