IL6 and colitis: The maternal diet is well known to be one of the major factors influencing offspring microbial composition (193), but more recently, maternal HFD has been shown to modulate susceptibility to diseases, as well as exacerbate offspring susceptibility to chemically induced colitis (194–197) associated with increased IL-1β, IL-6 and IL-17 expression and upregulated NF-κB signaling (194).