Chromosome X Open Reading Frame 21 (CXorf21) has been observed to be a susceptibility gene in SLE (34), and here, Chromosome 11 Open Reading Frame 31 (C11orf31) and Chromosome 1 Open Reading Frame 162 (C1orf162) were broadly expressed in subtypes of T and B cells and monocytes. The gene discussed is C1orf162; the disease is systemic lupus erythematosus.