To further elucidate whether the hematopoietic cell- or non-hematopoietic cell-expressed P2RX1 contributed to the progression of AP, bone marrow chimeras were generated using WT mice and P2RX1-KO mice (WT → WT, KO → KO, WT → KO, and KO → WT). This evidence concerns the gene P2RX1 and alkaline phosphatase measurement.