DUSP1 and obesity due to melanocortin 4 receptor deficiency: Studies showed that MKP-1 deficient protected mice from diet-induced obesity and diet or gene induced hepatic steatosis (35, 36).EGR1, namely, early growth response 1, played an essential role in the pathophysiological process of inflammation and tissue repairment (37). A previous bioinformatic study identified that the lower expression of hepatic EGR1 might promote NAFLD development (38).