LIAS and hyperinsulinemic hypoglycemia, familial, 4: Suppression burst pattern in neonates with refractory seizures may indicate severe brain malformation as well as metabolic diseases, e.g., sulphite oxidase deficiency, molybdenum cofactor deficiency, pyridoxine-dependent epilepsy, non-ketotic hyperglycinemia (Figures 2A,B), mitochondrial cytochrome c oxidase deficiency or pyruvate dehydrogenase complex deficiency (Figures 2C,D), and lipoic acid synthetase deficiency (66).