In particular, recent data show an association between obesity and headache disorders also in children (8, 9); in fact, the same pathophysiological mechanisms appear to be implicated in obesity and migraine such as thalamic activation, and the release of serotonin as a neurotransmitter along with adiponectin as an immune modulator, suggesting that lifestyle and behavioral differences may contribute to the migraine-obesity connection (10). The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.