TNF and juvenile idiopathic arthritis: TNF-α inhibitors, such as etanercept (human dimeric fusion protein which functions as a decoy receptor and binds to soluble TNF-α), adalimumab (human monoclonal antibody -mAb- which binds with high affinity both soluble and membrane-bound TNF-α) and infliximab (chimeric mAb which blocks both soluble and trans-membrane TNF-α) are widely used in JIA.