Figure 1 shows that patients with SCD and patients with OCI had significantly lower NCAPH2 methylation levels than the controls (both p < 0.001; Bonferroni corrected), but there was no difference between patients with SCD and patients with OCI (p > 0.1; Bonferroni corrected). Further comparison among the four groups showed that the NCAPH2 methylation levels were lower in patients with MCI and patients with AD than the controls, but there was no difference among patients with SCD, patients with MCI, and patients with AD (Supplementary Figure 1). Here, NCAPH2 is linked to Alzheimer disease.