Among the undetermined F-ADGs, CCNT1, DUSP9, HSPB1, IL6, LDLR, CCL2, and FLT1 were positively correlated with the severity of AD, while KCNJ10, JUP and LDLRAP1 were negatively correlated with the severity of AD (Figure 7, Supplementary Material 8). Here, LDLR is linked to Alzheimer disease.