Since in Luppi et al. (2019) the study focused on the brain, a dedicated study on the SpCo appears of particular interest concerning two main objectives: (i) to integrate and complete the knowledge of phosphorylation/dephosphorylation processes of Tau protein in the central nervous system during ST; (ii) to better define the possible parallelism of these processes with those occurring in tauopathies. This evidence concerns the gene MAPT and tauopathy.