LAMP1 and stroke disorder: In the current study, we found that the expression level of P62 and LAMP1 were significantly increased in the hippocampus at 24 h compared to the MCAO/R group after stroke, and the LC3-II/I ratio was significantly increased at 12 h after MCAO surgery and was decreased at 24 h after MCAO surgery in the hippocampus after EA treatment; this result might be involved in the neuroprotective effect of EA and post-stroke 12 h and 24 h might be the key time points for stroke intervention methods application.