Both second and third-line FDA-approved GIST TKIs (i.e., sunitinib and regorafenib) also target the KIT oncoprotein, but the objective response rates (ORR) for these drugs are only 6.8% (median PFS 5.6 month) and 4.5% (median PFS 4.8 month), respectively [9, 10]. Here, KIT is linked to gastrointestinal stromal tumor.