NPM1 and acute myeloid leukemia: Multivariable analyses indicated a HR of 0.57 (95% CI 0.35–0.92, p = 0.021) after adjustment for other prognostic variables like age, cytogenetic risk, NPM1 and FLT3-ITD mutation status, LDH, WBC and secondary AML (Table 2, Supplemental Table ST1 and Supplemental Figs. SF3 and SF4).