H. pylori antibody typing classification is mainly based on the expression of virulence protein CagA, VacA, Urease A and Urease B. CagA of H. pylori can accelerate the progress of gastric cancer and AG, in which tyrosine phosphorylated EPIYA modules play an important role in active gastritis, associating with the progression of diffuse-type of gastric cancer, especially in women26. The gene discussed is S100A8; the disease is gastritis.