NRXN1 and myeloid sarcoma: Among the 11 proteins, the contactin-associated protein-like 4 is involved in the formation and maintenance of myelinated axons18, and its transcript (CNTNAP4) was upregulated in the inactive lesion type; olfactomedin-like protein 3, a known marker of activated ramified microglia, and OLFML3 was also significantly upregulated in chronic active lesions and in NAWM; neurorexin-1 can be related to neurodegeneration in MS19, and NRXN1 was uniquely significantly upregulated in the chronic active lesion type associated with progressive MS.