GFAP, inter-alpha-trypsin inhibitor heavy chain H1, and H2, serum amyloid P-component, and actin cytoplasmic 1 protein were uniquely upregulated in AQP4-IgG+ NMOSD compared to all MS subtypes, AD and healthy controls (Fig. 6). The gene discussed is ITIH1; the disease is myeloid sarcoma.