Furthermore, SjS patients with either serological evidence of past EBV infection or recent infection/reactivation presented higher values of CXCR3+ CD4+ T cells (Th1) and CXCR3+ CXCR5+ CD4+ T cells (Tfh1) compared to those without serological evidence of active infection. The gene discussed is CXCR5; the disease is Epstein-Barr virus infection.