Considering the IgD/CD27 classification, the percentages of IgD+CD27− B-cells (naïve) were higher in SjS patients when compared to HC (p = 0.028) and RA patients (p = 0.043), and SjS patients also presented higher absolute counts of this subset compared to RA (p = 0.015). This evidence concerns the gene CD27 and rheumatoid arthritis.