NFKB1 and TNF receptor 1-associated periodic fever syndrome: In addition, infliximab treatment of PBMCs induces an anti-apoptotic effect in p.(Thr79Met) PBMCs and an increased level of the NF-κB p65 and c-Rel subunit, which explains why TRAPS patients carrying this mutation are refractory to this anti-TNF therapy53.