In summary, the current study revealed selective chemosensitizing effect of L. squarrosulus peptide extract to cisplatin-induced apoptosis in human lung cancer cells via suppression of integrin/FAK/Src/Akt survival signaling, downregulation of anti-apoptosis proteins (Mcl-1, Bcl-2), and upregulation of p53 as well as pro-apoptosis Bax proteins (Fig. 8). This evidence concerns the gene PROS1 and lung carcinoma.