When estimated in the same way, men APOE ε4 carriers took 12.7 (10.5–14.0) years to progress from preclinical AD to AD dementia, while women APOE ε4 non-carriers took 20.2 (13.5–23.7) years and men APOE ε4 non-carriers took 24.0 (17.7–30.9) years. This evidence concerns the gene APOE and Alzheimer disease.