We performed frequency matching for APOE ε4 allele carriage between preclinical AD and MCI due to AD cohort, and calculated the time for a subject to convert from the preclinical to prodromal stage to examine the effect of the different APOE4 ε4 allele distributions between preclinical AD and MCI due to AD cohorts on the estimated results (Supplementary Fig. S1). Here, APOE is linked to Alzheimer disease.