Also expressed at lower levels in MS/CIS patients relative to controls were alpha-1B-glycoprotein, biotinidase (BTD), follistatin-related protein 1 (FSTL1), haptoglobin (HP), immunoglobulin superfamily containing leucine-rich repeat protein, inter-alpha-trypsin inhibitor heavy chain H2 (ITIH2), serum amyloid A-4 protein, and transferrin (TF). The gene discussed is BTD; the disease is in situ carcinoma.