Thus, there was a substantial shift in the proteome patterns of patients in the two groups of cohort 1, where MS patients and controls in group B, but not in group A, had increased levels of IgG and the fibrinogen proteins FGA, FGB, and FGG but decreased levels of proteins linked to compensatory mechanisms to reduce inflammation, such as proteins involved in regulation of the purine nucleotide catabolic process and the G-protein coupled receptor signalling pathway103. Here, FGG is linked to myeloid sarcoma.