Using human primary NK cells from malaria-naïve healthy donors, H3-specific Abs induced significant CD107a upregulation and cytokine expression (median expression [interquartile range (IQR)]: CD107a: 11.1% [10.2–13.1%], IFNγ: 7.0% [5.1–10.8%], TNFα: 6.2% [3.9–6.7%]), whereas SIV gp120 did not (median expression [IQR]: CD107a: 1.3% [0.7–1.6%], IFNγ: 0.3% [0.1–0.7%], TNFα: 0.0% [0.0–0.3%]). This evidence concerns the gene ITIH4 and malaria.