IGHG3 and malaria: We observed that the majority of Ab-mediated NK cell activation in women with placental malaria was driven by IgG1, even though a recent study identified malaria-specific IgG1 and IgG3, and engagement with FcγRIIIa (linked to Ab-mediated NK cell activity), as key prediction parameters for protection in malaria RTS,S/AS01 vaccinees30.