CHAT and schizophrenia: Furthermore, the ChAT expression was only significantly reduced in male patients with schizophrenia having positive and negative symptoms (unpaired two-tailed t test, t = 2.885, P = 0.016), but not female patients with schizophrenia having negative symptoms (P = 0.667) or not (P = 0.381) (one-way ANOVA with post hoc Tukey’s test, F2, 11 = 1.059, P = 0.380).