HRH1 and schizophrenia: Meanwhile, the female patients with schizophrenia having positive and negative symptoms (P < 0.001), but not patients with schizophrenia having positive symptoms only (P = 0.560), showed decrease in the Hrh1 mRNA expression (one-way ANOVA with post hoc Tukey’s test, F2, 11 = 20.070, P = 0.302).