Although cluster 4 contained only a minority of FOXP3-transcribing cells, among its markers were RUNX3, which binds to the FOXP3 promoter inducing its transcription95, DUSP4 which stabilizes FOXP3 expression96 and MIR155HG, which is induced by FOXP3 and associates with breast tumor initiation97. This evidence concerns the gene RUNX3 and breast neoplasm.