Tumor-infiltrating CD4+ cells consisted of FOXP3+CD127− Treg, FOXP3−CD127+ Tconv but also a major proportion of FOXP3+CD127+ ActTconv, which according to the single-cell transcriptome analysis above resemble cluster 1 and, thus, possess an activated phenotype with immune-suppressive properties. The gene discussed is IL7R; the disease is neoplasm.