The increased expression of cytotoxic effector molecules GZMA, GZMB, GZMH, GZMM, GNLY, NKG7, and PRF178 but also of the thioredoxin function inhibitor TXNIP79, demonstrates a potent effector capacity to eliminate malignant cells and suppress tumor growth (Fig. 3f and Supplementary Fig. 9e). Here, GZMM is linked to neoplasm.