IFNA1 and neoplasm: Although in our study it was difficult to discern specific immune cell subtypes using bulk RNA sequencing, given that the weighted Cam_121 score was strongly negatively correlated with B cells, T cells and all immune cells (ρDistant-Metastases=No = −0.8, −0.73 and −0.75, respectively, with exact two-sided pDistant-Metastases=No < 2.2 × 10−16) and that IFN pathways dominated gene set enrichment, we regard this as further evidence that a successful immune-mediated cytotoxic anti-tumour response exists in primary melanoma.