TFRC and head and neck squamous cell carcinoma: Given that HNSCC cells often manifest an increased intracellular iron concentration due to a high level of TFRC1 (transferrin receptor 1 responsible for cellular iron uptake)137 and a low abundance of ferroportin (responsible for iron efflux)138, ferroptosis-inducing therapy can be expected to effectively induce cell death in HNSCC cells without affecting normal tissue; see Fig. 3.