Motif analysis showed that rs6695584 changed the binding motif of BATF, which is an oncogenic TF described in types of cancers.34,35 BATF is one of the activator protein 1 (AP-1) TFs and the AP-1-BATF module could upregulate several marker genes such as IL17F, IL22, IL26, and IL23R in anaplastic large cell lymphoma.35 Here, the variation of risk SNP rs6695584 increased the binding of BATF with enhancer element, and consequently promotes the expression of lncSLCC1. The gene discussed is IL22; the disease is cancer.