Hexokinase 2 (HK2) is a pivotal kinase in the glycolytic pathway.27 Previous studies have demonstrated that HK2 activity is remarkably increased in various malignant neoplasms, as well as in CRC.28 Our previous data showed that lncSLCC1 could activate glycolysis, promote CRC, and regulate HK2 expression. Here, HK2 is linked to cancer.