HDAC3-Y298H-v5 in D2R-MSNs had similarly not affected anxiety-like behaviors (two-way ANOVA RM: main effect of arm: F(1,36) = 494.8, p < 0.0001; no main effect of virus: F(1,36) = 0.2966, p = 0.5894; no interaction: F(1,36) = 0.609, p = 0.4403; Fig. 7F,G). The gene discussed is HDAC3; the disease is Anxiety.