RELA and cancer: NF-κB/RelA ablation also abolished the response to Oxali + anti–PD-L1 (Fig. 8A), consistent with its requirement for MHC-I and IFNγR2 induction (Fig. 8B and SI Appendix, Fig. S17A), Thus, Oxali-induced up-regulation of MHC-I AgPPM genes in malignant cells is important for the final recognition and killing stage of the cancer-immunity cycle (25) but has no role in ICIT-induced CTL reinvigoration.