On the other hand, the Ad-CEA+N-803+OX40+4-1BB+PD-L1 combination resulted in significant tumor growth inhibition compared with control (p<0.001) and OX40+4-1BB (p=0.0416) and PD-L1 (p=0.0063) single modality treatments, but the frequency of cured animals remained at 50% (3/6 mice). Here, CD274 is linked to neoplasm.