Meta-analysis of all the repeats of hexatherapy regimen studies for the ‘cool’ 4T1 tumor model shows that the hexatherapy regimen is required to achieve tumor growth control in 58% of the treated animals (figure 7A), whereas only two IO agents were needed to achieve the same rate in the MC38-CEA tumor model (figure 2H). This evidence concerns the gene CEACAM5 and neoplasm.