CD4 and neoplasm: PMN-MDSC and M-MDSC use different mechanisms of immunosuppression; therefore, limiting both populations is important to foster anti-tumor immunity.29 In addition, the FoxP3+CD4+ Treg population was decreased by all the multimodal combination treatments and by Ad-Twist+N-803 and OX40+4-1BB single modal therapies (figure 6C).