CD274 and neoplasm: To achieve this, we designed a multimodal combination treatment composed of adenovirus-based TAA-targeting vaccine + N-803 to engage the effector cells, OX40+4-1BB agonists to enhance the anti-tumor activity, PD-L1 blockade to enable immune response in the TME, and docetaxel to induce immunogenic cell death and activate a different population of TAA-specific T cells (evolve).