We strategically designed a combination treatment regimen composed of adenovirus-based vaccine (Ad-CEA or Ad-Twist), N-803, OX40, 4-1BB, PD-L1, and docetaxel (also referred to as ‘hexatherapy’) and hypothesized that MC38-CEA and 4T1 tumor models will have varying response to multimodal immunotherapeutic combinations involving an ICI. Here, TNFRSF4 is linked to neoplasm.