ACE and cardiac hypertrophy: The I allele was associated with optimal vascular tension, dominance of slow-twitch muscle fibers, and amenability to enhanced aerobic endurance; alternatively, the D allele was associated with increased ACE activity and abundance of fast muscle fibers beneficial to the development of speed–strength qualities, as well as predisposition for arterial hypertension and myocardial hypertrophy [14, 25–27].