On the other hand, the Histone-Lysine N-Methyltransferase EZH2, whose gene expression is regulated by various miRNAS upregulated in CD, such as hsa-miR-484, hsa-miR-124-3p, hsa-let-7b-5p, hsa-miR-30d-5p, hsa-miR-98 and hsa-miR-101-3p (Fig. 1), plays an important role in maintaining intestinal barrier integrity and immune homeostasis in IBD through the regulation of TNFα signaling pathways, among other inflammatory molecules [80, 81]. This evidence concerns the gene TNF and Cowden disease.