CTLA4 and neoplasm: This anti-CTLA-4 induced Treg depletion in the TME is suggested to be mediated by Fc-gamma-receptor expressing macrophages via a mechanism of antibody dependent cell-mediated cytotoxicity (ADCC) [78, 80–83], the dual action of anti-CTLA-4 on intratumoral and peripheral Tregs resting on the higher expression of CTLA-4 on exhausted tumor-infiltrating Tregs [84].