As adenomyotic and endometriotic lesions are both ectopic endometrium and share the same hallmark of cyclic bleeding [12], our results suggest that, as in endometriosis, sensory nerve-derived neuropeptides such as SP and CGRP and sympathetic nerve-derived neurotransmitters such as noradrenaline may be actively involved in the promotion of adenomyosis progression through their respective receptors on adenomyotic lesions. The gene discussed is TFF2; the disease is adenomyosis.