TFF2 and endometriosis: As adenomyotic and endometriotic lesions are both ectopic endometrium and share the same hallmark of cyclic bleeding [12], our results suggest that, as in endometriosis, sensory nerve-derived neuropeptides such as SP and CGRP and sympathetic nerve-derived neurotransmitters such as noradrenaline may be actively involved in the promotion of adenomyosis progression through their respective receptors on adenomyotic lesions.