Multiple linear regression incorporating age, menstrual phase, parity, presence or absence of uterine fibroids, presence or absence of deep endometriosis, presence or absence of ovarian endometriomas, and group identity (adenomyosis or control) confirmed that adenomyotic lesions were associated with higher staining of RAMP1, CRLR, NK1R, ADRB2 but lower staining of α7nAChR in both epithelial and stromal components (all p-values < 1.2 × 10− 12, all R2’s ≥ 0.63). This evidence concerns the gene CALCRL and endometriosis.