EGFR and cancer: Anti-EGFR antibodies play an anti-tumor role by binding to cell surface receptors and interfering ligand binding, which leads to the inhibition of its downstream signaling pathway. Approved bare antibodies for EGFR (i.e.panituzumab, nimotuzumab, cetuximab, and necitumumab) have demonstrated their therapeutic efficacy in malignant tumors, but are usually used in combination with chemotherapy drugs to achieve significant clinical efficacy [36, 37].