EGFR and esophageal squamous cell carcinoma: As shown in Fig. 3a, b, The results showed that compared with the control, the cell invasion and migration of ESCC cells were significantly suppressed in the sgCALM1-1 group compared with control group; however, a stronger increase was observed in the sgCALM1-1 group plus EGFR inhibitors group (p < 0.001).