However after the loss of E6/E7, the content of ANT3 and FBLN1 in KoE6/E7 SiHa were downregulated compared to wide type SiHa by qPCR and immunofluorescence, which indicated the expression of ANT3 and FBLN1 in cervical cancer may be affected by HPV infection (Fig. 4 c and Fig. 4d). The gene discussed is FBLN1; the disease is cervical cancer.