RRAGA and colorectal cancer: In colorectal cancer (CRC), overexpression of RNF152 has been show to inhibit CRC cell proliferation both in vitro and in vivo by inactivating the mechanistic target of rapamycin complex 1 (mTORC1) via targeting RagA for K63-linked ubiquitination and inducing autophagy and apoptotic cell death [12].