The results showed that FT3 in patients with hyperthyroidism was significantly negatively correlated with liver fat content and was independent from other well-established NAFLD-related risks factors including BMI, TG, CRP, IL-6, etc. These findings expanded the significant association of thyroid hormone and NAFLD in hypothyroidism and euthyroidism population, elevated thyroid hormone levels can reduce liver fat content regardless of the thyroid functional status of the population. This evidence concerns the gene CRP and hypothyroidism.