3 ACE2 variants were correlated with higher risk of AF in participants with T2D during follow-up period as follows: rs2074192 (CC, adjusted RR = 2.55, 95% CI 1.35–4.80, P = 0.004), rs4240157 (CC + CT, adjusted RR = 2.26, 95% CI 1.27–4.04, P = 0.006), rs4646188 (TT, adjusted RR = 2.37, 95% CI 1.16–4.86, P = 0.018), as shown in Table 1. The gene discussed is ACE2; the disease is type 2 diabetes mellitus.