Consistently, overexpression of miR-139-3p or knockdown of BCAR4 overtly reduced the cell viability of ESCC cells, while overexpression of ELAVL1 recovered the decreased cell viability induced by miR-139-3p overexpression or shBCAR4 both in EC109 and TE-1 cells (Figure 4k).Expectedly, miR-139-3p was downregulated in ESCA tissues while ELAVL1 was overexpressed in Esophageal Carcinoma (ESCA) from the HCMDB datasets (Figure 5a). This evidence concerns the gene ELAVL1 and esophageal squamous cell carcinoma.