The higher incidence of hypertriglyceridemia during pregnancy is due to an increase in estrogens, progestogens, and human placental lactogen, which reduce the activity of lipoprotein lipase (LPL) by 85%.10Likewise, estrogens increase the hepatic synthesis of triglycerides and VLDL.11In contrast, insulin resistance increases, which lowers LPL activity in adipocytes.12In general, the concentration of triglycerides typically increases 2 to 3 times,5, 8especially in the third trimester. The gene discussed is LPL; the disease is hypertriglyceridemia.