The parental SK-N-SH cells, clone 2 and another 3 clones with double peak in the APOE sequence (clones 5, 6 and 7) were differentiated along with 4 CRISPR control clones (CRISPR control 1, 2, 3 and 4) that had undergone the CRISPR process and the monoclonal selection but had no alteration in the APOE sequence (Figure 1C, CRISPR/Cas9 edited cells), and the SH-SY5Y neuroblastoma cells, a neuroblastic subclone of the SK-N-SH cells. This evidence concerns the gene APOE and neuroblastoma.