In summary, the administration of the combination of TLR7 agonist (GS-986) with N6-LS and PGT121 to macaques that initiated ART 14 days after SHIV-1157ipd3N4 infection was associated with a modest delay in viral rebound, despite limited dosing of bnAbs due to ADA. This evidence concerns the gene TLR7 and infection.