In a recent study by Barouch et al., in macaques that initiated ART 1 year after SHIV-SF162P3 infection and were virologically suppressed for 2.5 years, the administration of 10 infusions of PGT121 or GS-9721 (Fc-modified version of PGT121) with TLR7 agonist prevented viral rebound in 41% (7 of 17) of animals following ART interruption [24]. Here, TLR7 is linked to infection.