Interestingly, and in accordance with our recent findings in human AIH (36), the liver-infiltrating Th1 cells in Alb-iGP_Smarta mice were marked by coproduction of IFN-γ and TNF in liver (Figure 3F and Supplemental Figure 2B; P = 0.0012), indicating potent inflammatory activation. This evidence concerns the gene ALB and autoimmune hepatitis.