ASPN expression in the tumor microenvironment is associated with increasing Gleason grade and worse outcomes [29, 30, 31, 32, 33], but how ASPN expression in CAFs adjacent to Gleason grade 4 prostate cancer with cribriform morphology compares to CAFs in Gleason grade 4 prostate cancer with noncribriform morphology is not known. The gene discussed is ASPN; the disease is neoplasm.