The percentages of ASPN+NT5E+ cells and ASPN+NT5E− cells were significantly lower than the percentage of ASPN−NT5E+ cells in benign prostate stroma (p ≤ 0.0005); however, only the ASPN+NT5E− cells and the ASPN+NT5E+ cells detected in the stroma adjacent to benign prostate glands were enriched in the cribriform prostate tumor microenvironment, while the more abundant ASPN−NT5E+ cells were significantly decreased (Figure 4E). Here, ASPN is linked to medical procedure.