Stroma was additionally analyzed for dual expression of FAP and ASPN. ASPN+FAP+ cells and ASPN−FAP+ cells were equally abundant at low levels in stroma adjacent to benign prostate; however, ASPN+FAP+ cells were selectively enriched in the cribriform prostate tumor microenvironment compared to ASPN−FAP+ cells. Here, FAP is linked to prostate neoplasm.