Interestingly, interrogation of specific pleiotropic genes showed that the gene C1QA that encodes a major constituent of the complement system subcomponent C1, was upregulated and mapped to significantly enriched GO terms associated with (i) immune/defense response to virus infection, (ii) glial cell response, (iii) neuron differentiation, and (iv) synapse (Supplementary file 8, gProfiler: Immune-neural-synaptic pleiotropic DEGs’), as well as synaptic pruning (Table 4). Here, C1QA is linked to viral infectious disease.